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KMID : 0377519880130010045
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Chung-Ang Journal of Medicine
1988 Volume.13 No. 1 p.45 ~ p.57
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Pathological Study on the Carcinogenic Effects of7, 12-Dimethylbenzanthracene Modulated by Phorbol Ester and Administration Route
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Abstract
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To observe the carcinogenic effects of 7, 12-dimethylbenzanthracene modulated by the application of phorbol ester and the changes of administration route of DMBA, a pathological study was carried out on the female rats of 50 days-old by analysing incidence, histopathological progession and relationship of ad-ministration route and/or the promotor application in acute and chronic experimental groups.
The results were as follows:
1. Tumor incidence was higher by the oral administration than topical application of DMBA and earlier tumefaction was noted by the application of the promotor.
2. Early histopathological changes were mild acanthosis and moderate inflammation by the promotor and more prominent acanthosis and papillomatosis by additional DMBA with repeated promotor application´.
3. Most common tumor was adenocarcinoma even in topical application of DMBA, followed by fibroadenoma, fibroma and squamous cell carcinoma. Incidence of fibroma was increased by topical application of DMBA.
4. Histopathological patterns of the tumors were mixed, cribriform, microglandular, clear cell and solid types. Some of them showed background of adenomtous or fibroadenomatous tumors.
5. In oral administration group of DMBA,´the increased tumor incidence was noted in topical applied area than non-applied area.
Therefore, it was suggested that carcinogenicity of DMBA was promoted by phorbol ester, inducing. adenocarcinoma of various hitopathologcal types. The change of administration route of the carcinogen could cause the histopathologic difference in tumor types.
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